Paired Electrolysis-Enabled Arylation of Quinoxalin-2(1 H )-ones

作者：Jia-Cheng Hou, Jun Jiang, Yan-Cui Wen, Yan-Yan Zeng, Yuhan Lu, Jiasheng Wang, Li‐Juan Ou, Wei‐Min He · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.4c00087 · 被引用次数：27 · 研究领域：Synthesis and Biological Evaluation、Radical Photochemical Reactions、CO2 Reduction Techniques and Catalysts

The first paired electrolysis-enabled arylation of quinoxalin-2(1 H )-ones was achieved using cyanoarenes as the arylation reagents. A variety of 3-arylquinoxalin-2(1 H )-ones with various important functional groups were obtained in moderate to good yields under metal- and chemical oxidant-free conditions. With a pair of reductive and oxidative processes occurring among the substrates and reaction intermediates, the power consumption can be dramatically reduced.