FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway

作者：Feiyan Cheng, Jingyuan Wang, Rongli Wang, Rumeng Pan, Zhiwei Cui, Lijun Wang, Lihui Wang, Xinyuan Yang · 发表于：Molecular and Cellular Endocrinology · 年份：2024 · DOI：10.1016/j.mce.2024.112248 · 被引用次数：13 · 研究领域：Hippo pathway signaling and YAP/TAZ、Reproductive Biology and Fertility、Kruppel-like factors research

Young women undergoing anticancer treatment are at risk of premature ovarian failure (POF). Endometrial-derived stem cells (EnSCs) have demonstrated significant therapeutic potential for treating ovarian insufficiency, although the underlying mechanisms remain to be fully understood. This study aims to further investigate the therapeutic effects of EnSCs, particularly through the paracrine action of fibroblast growth factor 2 (FGF2), on POF. The findings show that exogenous FGF2 enhances the survival of ovarian granulosa cells damaged by cisplatin. FGF2 stimulates the proliferation of these damaged cells by suppressing the Hippo signaling pathway and activating YAP expression. In vivo experiments also revealed that FGF2 treatment significantly improves ovarian reserve and endocrine function in mice with POF. These results suggest that FGF2 can boost the proliferative capacity of damaged ovarian granulosa cells through the Hippo-YAP signaling pathway, providing a theoretical foundation for using EnSCs and FGF2 in clinical treatments for POF.