ROS-responsive thermosensitive polypeptide hydrogels for localized drug delivery and improved tumor chemoimmunotherapy

作者：Fujiang Li, Junfeng Ding, Zhenyu Li, Yan Rong, Chaoliang He, Xuesi Chen · 发表于：Biomaterials Science · 年份：2024 · DOI：10.1039/d4bm00241e · 被引用次数：29 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、Cancer Research and Treatments

. Following intratumoral injection into mice bearing B16F10 melanoma, the Dox/R848/aPD-1 co-loaded hydrogel effectively inhibited tumor growth, prolonged animal survival time and promoted anti-tumor immune responses with low systemic toxicity. In the postoperative model, the Dox/R848/aPD-1 co-loaded hydrogel exhibited enhanced tumor recurrence prevention and long-term immune memory effects. Thus, the hydrogel-based local chemoimmunotherapy system demonstrates potential for effective anti-tumor treatment and suppression of tumor recurrence.