Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery in vivo

作者：Tian Zhang, Han Yin, Li Yu, Haiyin Yang, Kun Ge, Jinchao Zhang, Qing Yuan, Xuyan Dai, Abid Naeem, Yuhua Weng, Yuanyu Huang, Xing-Jie Liang · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.109804 · 被引用次数：84 · 研究领域：RNA Interference and Gene Delivery、Advanced biosensing and bioanalysis techniques、Lipid Membrane Structure and Behavior

nucleic acids delivery faces significant biological challenges. Lipid nanoparticles (LNPs) possess several advantages, such as simple preparation, high stability, efficient cellular uptake, endosome escape capabilities, etc., making them suitable for delivery vectors. However, the extensive hepatic accumulation of LNPs poses a challenge for successful development of LNPs-based nucleic acid therapeutics for extrahepatic diseases. To overcome this hurdle, researchers have been focusing on modifying the surface properties of LNPs to achieve precise delivery. The review aims to provide current insights into strategies for LNPs-based organ-selective nucleic acid delivery. In addition, it delves into the general design principles, targeting mechanisms, and clinical development of organ-selective LNPs. In conclusion, this review provides a comprehensive overview to provide guidance and valuable insights for further research and development of organ-selective nucleic acid delivery systems.