Strategic white matter hyperintensity locations associated with post-stroke cognitive impairment: A multicenter study in 1568 stroke patients

作者：Mirthe Coenen, Floor A.S. de Kort, Nick A. Weaver, Hugo J. Kuijf, Hugo P. Aben, Hee‐Joon Bae, Régis Bordet, Christopher Chen, Anna Dewenter, Thomas Doeven, Thibaut Dondaine, Marco Duering, Rong Fang, Ruben S. van der Giessen, Jonguk Kim, Beom Joon Kim, Paul L.M. de Kort, Peter J. Koudstaal, Minwoo Lee, Jae‐Sung Lim, Renaud Lopes, Robert J. van Oostenbrugge, Julie Staals, Kyung‐Ho Yu, Geert Jan Biessels, J. Matthijs Biesbroek · 发表于：International Journal of Stroke · 年份：2024 · DOI：10.1177/17474930241252530 · 被引用次数：21 · 研究领域：Spatial Neglect and Hemispheric Dysfunction、Dementia and Cognitive Impairment Research、Traumatic Brain Injury Research

BACKGROUND: Post-stroke cognitive impairment (PSCI) occurs in up to 50% of stroke survivors. Presence of pre-existing vascular brain injury, in particular the extent of white matter hyperintensities (WMH), is associated with worse cognitive outcome after stroke, but the role of WMH location in this association is unclear. AIMS: We determined if WMH in strategic white matter tracts explain cognitive performance after stroke. METHODS: Individual patient data from nine ischemic stroke cohorts with magnetic resonance imaging (MRI) were harmonized through the Meta VCI Map consortium. The association between WMH volumes in strategic tracts and domain-specific cognitive functioning (attention and executive functioning, information processing speed, language and verbal memory) was assessed using linear mixed models and lasso regression. We used a hypothesis-driven design, primarily addressing four white matter tracts known to be strategic in memory clinic patients: the left and right anterior thalamic radiation, forceps major, and left inferior fronto-occipital fasciculus. RESULTS: The total study sample consisted of 1568 patients (39.9% female, mean age = 67.3 years). Total WMH volume was strongly related to cognitive performance on all four cognitive domains. WMH volume in the left anterior thalamic radiation was significantly associated with cognitive performance on attention and executive functioning and information processing speed and WMH volume in the forceps major with inform...