EV‐COMM: A database of interspecies and intercellular interactions mediated by extracellular vesicles

作者：Jingyu Chen, Jingjing Lin, Weiyi Wang, Haining Huang, Zhizhen Pan, Guozhu Ye, Sijun Dong, Yi Lin, Congtian Lin, Qiansheng Huang · 发表于：Journal of Extracellular Vesicles · 年份：2024 · DOI：10.1002/jev2.12442 · 被引用次数：14 · 研究领域：Extracellular vesicles in disease、interferon and immune responses、RNA regulation and disease

Intra- and inter-organismal interactions play a crucial role in the maintenance and function of individuals, as well as communities. Extracellular vesicles (EVs) have been identified as effective mediators for the communication both within and between species. They can carry and transport molecular cargoes to transmit biological messages. Several databases (ExoBCD, ExoCarta, EVpedia, EV-TRACK, Vesiclepedia) complied the cargoes information including DNA, RNA, protein, lipid and metabolite associated with EVs. Databases that refer to the complete records on both donor and recipient information are warranted to facilitate the understanding of the interaction across cells and species. In this study, we developed a database that compiled the records equipped with a structured process of EV-mediated interaction. The sources of donor and recipient were classified by cell type, tissues/organs and species, thus providing an extended knowledge of cell-cell, species-species interaction. The isolation and identification methods were presented for assessing the quality of EVs. Information on functional cargoes was included, where microRNA was linked to a prediction server to broaden its potential effects. Physiological and pathological context was marked to show the environment where EVs functioned. At present, a total of 1481 data records in our database, including 971 cell-cell interactions belonging to more than 40 different tissues/organs, and 510 cross-species records. The database ...