Design, synthesis and antiproliferative evaluation of tetrahydro-β-carboline histone deacetylase inhibitors bearing an aliphatic chain linker

作者：Jing Shi, Jiayun Wang, Xingjie Wang, Chao Qu, Changchun Ye, Xiuli Li, Xin Chen, Zhengshui Xu · 发表于：RSC Advances · 年份：2024 · DOI：10.1039/d4ra01672f · 被引用次数：8 · 研究领域：Histone Deacetylase Inhibitors Research、Cholinesterase and Neurodegenerative Diseases、Catalytic C–H Functionalization Methods

. Molecular docking of 13d was conducted to rationalize the high binding affinity for HDAC1. Therefore, this work provides a new structure design for HDAC inhibitors and also offers a promising treatment for solid tumors.