Astragalus Polysaccharide Enhances Voriconazole Metabolism under Inflammatory Conditions through the Gut Microbiota

作者：Xiaokang Wang, Xianjing Hu, Chunxiao Ye, Jingqian Zhao, Shing Cheng Tan, Liangbin Zhou, Chenyu Zhao, Kit Hang Wu, Xixiao Yang, Jinbin Wei, Mao‐Xun Yang · 发表于：Journal of Clinical and Translational Hepatology · 年份：2024 · DOI：10.14218/jcth.2024.00024 · 被引用次数：14 · 研究领域：Probiotics and Fermented Foods、Gut microbiota and health、Traditional Chinese Medicine Analysis

Background and Aims: polysaccharide (APS) can regulate VRC metabolism, thereby potentially mitigating its hepatotoxic effects. In this study, we aimed to explore the mechanism by which APS regulates VRC metabolism. Methods: to regulate the expression of the VRC-metabolizing enzyme CYP2C19 through the gut-liver axis. Results: transcription through the nuclear factor-κB signaling pathway. Conclusions: The study offers valuable insights into the mechanism by which APS alleviates VRC-induced liver damage, highlighting its immunomodulatory influence on hepatic tissues and its indirect regulatory control of VRC-metabolizing enzymes within hepatocytes.