Revisiting the potential value of vital signs in the real-time prediction of mortality risk in intensive care unit patients

作者：Pan Pan, Yue Wang, Chang Liu, Yanhui Tu, Haibo Cheng, Qingyun Yang, Fei Xie, Yuan Li, Lixin Xie, Yuhong Liu · 发表于：Journal Of Big Data · 年份：2024 · DOI：10.1186/s40537-024-00896-8 · 被引用次数：6 · 研究领域：Machine Learning in Healthcare、Sepsis Diagnosis and Treatment、Frailty in Older Adults

Abstract Background Predicting patient mortality risk facilitates early intervention in intensive care unit (ICU) patients at greater risk of disease progression. This study applies machine learning methods to multidimensional clinical data to dynamically predict mortality risk in ICU patients. Methods A total of 33,798 patients in the MIMIC-III database were collected. An integrated model NIMRF (Network Integrating Memory Module and Random Forest) based on multidimensional variables such as vital sign variables and laboratory variables was developed to predict the risk of death for ICU patients in four non overlapping time windows of 0–1 h, 1–3 h, 3–6 h, and 6–12 h. Mortality risk in four nonoverlapping time windows of 12 h was externally validated on data from 889 patients in the respiratory critical care unit of the Chinese PLA General Hospital and compared with LSTM, random forest and time-dependent cox regression model (survival analysis) methods. We also interpret the developed model to obtain important factors for predicting mortality risk across time windows. The code can be found in https://github.com/wyuexiao/NIMRF . Results The NIMRF model developed in this study could predict the risk of death in four nonoverlapping time windows (0–1 h, 1–3 h, 3–6 h, 6–12 h) after any time point in ICU patients, and in internal data validation, it is suggested that the model is more accurate than LSTM, random forest prediction and time-dependent cox regression model (area under re...