Coaxial dual-path electrochemical biosensing and logic strategy-based detection of lung cancer-derived exosomal PD-L1

作者：J. Liu, Liu Zd, Chun-Qin Zhao, Yuting Jiao, B. Li, Jiaju Shi, Zichao Chen, Zhen Zhang · 发表于：Nanoscale · 年份：2024 · DOI：10.1039/d4nr00412d · 被引用次数：14 · 研究领域：Advanced biosensing and bioanalysis techniques、Extracellular vesicles in disease、Anodic Oxide Films and Nanostructures

particles per mL, and the detection limit was 310 particles per mL. Compared to other sensors, the electrochemical biosensor designed in this study has a lower detection limit and a wider detection range. Furthermore, we also successfully identified lung cancer-derived ExoPD-L1 by analyzing multiple protein biomarkers expressed on exosomes through the "AND" logic strategy. This sensor platform is expected to realize highly sensitive detection and accurate analysis of multiple sources of ExoPD-L1 and provide ideas for the clinical detection of ExoPD-L1.