Global burden associated with 85 pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

作者：Mohsen Naghavi, Tomislav Meštrović, Authia P Gray, Anna Gershberg Hayoon, Lucien R Swetschinski, Gisela Robles Aguilar, Nicole Davis Weaver, Kevin S Ikuta, Erin Chung, Eve E Wool, Chieh Han, Daniel T Araki, Samuel B Albertson, Rose Bender, Greg Bertolacci, Annie J. Browne, Ben S. Cooper, Matthew Cunningham, Christiane Dolecek, Matthew C Doxey, Susanna Dunachie, Sama Ghoba, Georgina Haines–Woodhouse, Simon I Hay, Rebecca Hsu, Kenneth Iregbu, Hmwe Hmwe Kyu, Jorge R Ledesma, Jianing Ma, Catrin E. Moore, Jonathan F Mosser, Vincent Mougin, Pirouz Naghavi, Amanda Novotney, Víctor Rosenthal, Benn Sartorius, Andy Stergachis, Christopher Troeger, Avina Vongpradith, Magdalene K Walters, Han Yong Wunrow, Christopher J L Murray · 发表于：The Lancet Infectious Diseases · 年份：2024 · DOI：10.1016/s1473-3099(24)00158-0 · 被引用次数：292 · 研究领域：Zoonotic diseases and public health、COVID-19 epidemiological studies、Viral Infections and Outbreaks Research

BACKGROUND: Despite a global epidemiological transition towards increased burden of non-communicable diseases, communicable diseases continue to cause substantial morbidity and mortality worldwide. Understanding the burden of a wide range of infectious diseases, and its variation by geography and age, is pivotal to research priority setting and resource mobilisation globally. METHODS: We estimated disability-adjusted life-years (DALYs) associated with 85 pathogens in 2019, globally, regionally, and for 204 countries and territories. The term pathogen included causative agents, pathogen groups, infectious conditions, and aggregate categories. We applied a novel methodological approach to account for underlying, immediate, and intermediate causes of death, which counted every death for which a pathogen had a role in the pathway to death. We refer to this measure as the burden associated with infection, which was estimated by combining different sources of information. To compare the burden among all pathogens, we used pathogen-specific ratios to incorporate the burden of immediate and intermediate causes of death for pathogens modelled previously by the GBD. We created the ratios by using multiple cause of death data, hospital discharge data, linkage data, and minimally invasive tissue sampling data to estimate the fraction of deaths coming from the pathway to death chain. We multiplied the pathogen-specific ratios by age-specific years of life lost (YLLs), calculated with GBD ...