Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1 H )-ones with Activated Alcohols

作者：Lili Wang, Pengyuan Yang, Jinwei Yuan, Wei Lian, Xinrong Jin, Sanyu Zhang, Liangru Yang, Dongliang Xing · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.4c00309 · 被引用次数：18 · 研究领域：Radical Photochemical Reactions、Synthesis and Biological Evaluation、Oxidative Organic Chemistry Reactions

)-ones was developed by using xanthate salts as alcohol-activating groups for radical generation in the presence of tricyclohexylphosphine under visible-light-promoted conditions. The remarkable features of this reaction include a broad substrate scope, excellent functional group tolerance, mild conditions, and simple operation. Moreover, the synthetic utility of this reaction was validated by the success of two-step one-pot reactions, scale-up synthesis, and chemoselective radical monodeoxygenation of diols.