The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system

作者：Meiling Xin, Fangjie Bi, Chao Wang, Yuhong Huang, Yujia Xu, Shufei Liang, Tianqi Cai, Xiaoxue Xu, Ling Dong, Tianxing Li, Xueke Wang, Yini Fang, Zhengbao Xu, Meng Wang, Xinhua Song, Yanfei Zheng, Wenlong Sun, Lingru Li · 发表于：Journal of Advanced Research · 年份：2024 · DOI：10.1016/j.jare.2024.04.005 · 被引用次数：27 · 研究领域：Circadian rhythm and melatonin、Sleep and related disorders、Plant and Biological Electrophysiology Studies

BACKGROUND: The treatment of metabolic system, cardiovascular system, and nervous system diseases remains to be explored. In the internal environment of organisms, the metabolism of substances such as carbohydrates, lipids and proteins (including biohormones and enzymes) exhibit a certain circadian rhythm to maintain the energy supply and material cycle needed for the normal activities of organisms. As a key factor for the health of organisms, the circadian rhythm can be disrupted by pathological conditions, and this disruption accelerates the progression of diseases and results in a vicious cycle. The current treatments targeting the circadian rhythm for the treatment of metabolic system, cardiovascular system, and nervous system diseases have certain limitations, and the identification of safer and more effective circadian rhythm regulators is needed. AIM OF THE REVIEW: To systematically assess the possibility of using the biological clock as a natural product target for disease intervention, this work reviews a range of evidence on the potential effectiveness of natural products targeting the circadian rhythm to protect against diseases of the metabolic system, cardiovascular system, and nervous system. This manuscript focuses on how natural products restore normal function by affecting the amplitude of the expression of circadian factors, sleep/wake cycles and the structure of the gut microbiota. KEY SCIENTIFIC CONCEPTS OF THE REVIEW: This work proposes that the circadian...