Long-term variations of urban–Rural disparities in infectious disease burden of over 8.44 million children, adolescents, and youth in China from 2013 to 2021: An observational study

作者：Li Chen, Yi Xing, Yi Zhang, Junqing Xie, Binbin Su, Jianuo Jiang, Mengjie Geng, Xiang Ren, Tongjun Guo, Wen Yuan, Qi Ma, Manman Chen, Mengjie Cui, Jieyu Liu, Yi Song, Liping Wang, Yanhui Dong, Jun Ma · 发表于：PLoS Medicine · 年份：2024 · DOI：10.1371/journal.pmed.1004374 · 被引用次数：18 · 研究领域：Zoonotic diseases and public health、Vaccine Coverage and Hesitancy、COVID-19 epidemiological studies

BACKGROUND: An accelerated epidemiological transition, spurred by economic development and urbanization, has led to a rapid transformation of the disease spectrum. However, this transition has resulted in a divergent change in the burden of infectious diseases between urban and rural areas. The objective of our study was to evaluate the long-term urban-rural disparities in infectious diseases among children, adolescents, and youths in China, while also examining the specific diseases driving these disparities. METHODS AND FINDINGS: This observational study examined data on 43 notifiable infectious diseases from 8,442,956 cases from individuals aged 4 to 24 years, with 4,487,043 cases in urban areas and 3,955,913 in rural areas. The data from 2013 to 2021 were obtained from China's Notifiable Infectious Disease Surveillance System. The 43 infectious diseases were categorized into 7 categories: vaccine-preventable, bacterial, gastrointestinal and enterovirus, sexually transmitted and bloodborne, vectorborne, zoonotic, and quarantinable diseases. The calculation of infectious disease incidence was stratified by urban and rural areas. We used the index of incidence rate ratio (IRR), calculated by dividing the urban incidence rate by the rural incidence rate for each disease category, to assess the urban-rural disparity. During the nine-year study period, most notifiable infectious diseases in both urban and rural areas exhibited either a decreased or stable pattern. However, a si...