Genome Mining Reveals a UbiA-Type Prenyltransferase Access to Farnesylation of Diketopiperazines

作者：Xiaotian Yu, Chuanteng Ma, Wenxue Wang, Jing Ge, Zian Wang, Jiaqi Lin, Qian Che, Guojian Zhang, Tianjiao Zhu, Dehai Li · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c00714 · 被引用次数：11 · 研究领域：Microbial Natural Products and Biosynthesis、Plant biochemistry and biosynthesis、Marine Sponges and Natural Products

UbiA-type prenyltransferases (PTases) are significant enzymes that lead to structurally diverse meroterpenoids. Herein, we report the identification and characterization of an undescribed UbiA-type PTase, FtaB, that is responsible for the farnesylation of indole-containing diketopiperazines (DKPs) through genome mining. Heterologous expression of the fta gene cluster and non-native pathways result in the production of a series of new C2 -farnesylated DKPs. This study broadens the reaction scope of UbiA-type PTases and expands the chemical diversity of meroterpenoids.