Cooking with liquefied petroleum gas or biomass and fetal growth outcomes: a multi-country randomised controlled trial

作者：William Checkley, Lisa M. Thompson, Shakir Hossen, Laura Nicolaou, Kendra N. Williams, Stella M. Hartinger, Marilú Chiang, Kalpana Balakrishnan, Sarada S. Garg, Gurusamy Thangavel, Vigneswari Aravindalochanan, Ghislaine Rosa, Alexie Mukeshimana, Florien Ndagijimana, John P. McCracken, Anaité Díaz-Artiga, Sheela Sinharoy, Lance A. Waller, Jiantong Wang, Shirin Jabbarzadeh, Yunyun Chen, Kyle Steenland, Miles A. Kirby, Usha Ramakrishnan, Michael Johnson, Ajay Pillarisetti, Eric D. McCollum, Rachel Craik, Eric O. Ohuma, Víctor G. Dávila‐Román, Lisa de las Fuentes, Suzanne Simkovich, Jennifer L. Peel, Thomas Clasen, Aris T. Papageorghiou, Gloriose Bankundiye, Dana Boyd Barr, Vanessa Burrowes, Alejandra Bussalleu, Devan Campbell, Eduardo Canúz, Adly Castañaza, Maggie L. Clark, Mary E. Crocker, Oscar De León, Ephrem Dusabimana, Lisa Elon, Juan Gabriel Espinoza, Irma Pineda Fuentes, Ahana Ghosh, Dina Goodman, Savannah Gupton, Sarah Hamid, Steven A. Harvey, Mayarí Hengstermann, Ian Hennessee, Phabiola Herrera, Marjorie Howard, Penelope P. Howards, Lindsay M. Jaacks, Katherine Kearns, Jacob Kremer, Margaret A. Laws, Pattie Lenzen, Jiawen Liao, Amy Lovvorn, Jane Mbabazi, Julia N. McPeek, Rachel Meyers, J. Jaime Miranda, Erick Mollinedo, Libny Monroy, Krishnendu Mukhopadhyay, Bernard Mutariyani, Luke P. Naeher, Abidan Nambajimana, Durairaj Natesan, Azhar Nizam, Jean de Dieu Ntivuguruzwa, Ricardo Piedrahita, Naveen Puttaswamy, Elisa Puzzolo, Ashlinn Quinn, Karthikeyan D. Rajamani, Sarah Rajkumar, Rengaraj Ramasami, Alexander Ramirez, P. Barry Ryan, Sudhakar Saidam, Zoë Sakas, Sankar Sambandam, Jeremy A. Sarnat, Kirk R. Smith, Damien Swearing, Ashley Toenjes, Lindsay J. Underhill, Jean Damascene Uwizeyimana, Viviane Valdes, Amit Verma, Megan Warnock, Wenlu Ye, Bonnie N. Young, Ashley Younger, Libny Monroy-Alarcon, Á. Durante, Claudia López-Ortega, Maria Fernanda González, Lakshminarayanan Sowrirajan, Shanthi P. Paramanandam, K Shanmugavadivu, V Sudharsanan, Suresh Seshadri, Adhemir E. Yupanqui-Fredes, Mario Hancco-Gomez, Ronald Apaza, Juan F. Persivale-Calle, Elizabeth Quispe, Carlos Leon-Ponce, Victor Villar-Gonzales, Rebeca Andrade-Salas, Jhon E. Herrera, Luzdelia Ramos-Mamani, Yessica Lopez, Giovanna Quiza, Yadel Hinojosa, Madeluz Gomez-Quispe, Gery Frisancho-Parada, Danielle I. Mendoza-Apaza, Luz R. Quispe-Flores, Niyitegeka F Xavier, Grace Utfimana, Elie Tuzayisenga, Valens Nkurunziza · 发表于：The Lancet Global Health · 年份：2024 · DOI：10.1016/s2214-109x(24)00033-0 · 被引用次数：14 · 研究领域：Energy and Environment Impacts、Air Quality and Health Impacts、Atmospheric chemistry and aerosols

Background Household air pollution might lead to fetal growth restriction during pregnancy. We aimed to investigate whether a liquefied petroleum gas (LPG) intervention to reduce personal exposures to household air pollution during pregnancy would alter fetal growth. Methods The Household Air Pollution Intervention Network (HAPIN) trial was an open-label randomised controlled trial conducted in ten resource-limited settings across Guatemala, India, Peru, and Rwanda. Pregnant women aged 18–34 years (9–19 weeks of gestation) were randomly assigned in a 1:1 ratio to receive an LPG stove, continuous fuel delivery, and behavioural messaging or to continue usual cooking with biomass for 18 months. We conducted ultrasound assessments at baseline, 24–28 weeks of gestation (the first pregnancy visit), and 32–36 weeks of gestation (the second pregnancy visit), to measure fetal size; we monitored 24 h personal exposures to household air pollutants during these visits; and we weighed children at birth. We conducted intention-to-treat analyses to estimate differences in fetal size between the intervention and control group, and exposure–response analyses to identify associations between household air pollutants and fetal size. This trial is registered with ClinicalTrials.gov (NCT02944682). Findings Between May 7, 2018, and Feb 29, 2020, we randomly assigned 3200 pregnant women (1593 to the intervention group and 1607 to the control group). The mean gestational age was 14·5 (SD 3·0) weeks ...