Establishment of a prognostic model for gastric cancer patients who underwent radical gastrectomy using machine learning: a two-center study

作者：Tong Lu, Miao Lü, Haonan Liu, Daqing Song, Zhengzheng Wang, Yahui Guo, Fang Yu, Qi Chen, Tao Li · 发表于：Frontiers in Oncology · 年份：2024 · DOI：10.3389/fonc.2023.1282042 · 被引用次数：16 · 研究领域：Gastric Cancer Management and Outcomes、Esophageal Cancer Research and Treatment、Inflammatory Biomarkers in Disease Prognosis

Objective: Gastric cancer is a prevalent gastrointestinal malignancy worldwide. In this study, a prognostic model was developed for gastric cancer patients who underwent radical gastrectomy using machine learning, employing advanced computational techniques to investigate postoperative mortality risk factors in such patients. Methods: Data of 295 patients with gastric cancer who underwent radical gastrectomy at the Department of General Surgery of Affiliated Hospital of Xuzhou Medical University (Xuzhou, China) between March 2016 and November 2019 were retrospectively analyzed as the training group. Additionally, 109 patients who underwent radical gastrectomy at the Department of General Surgery Affiliated to Jining First People's Hospital (Jining, China) were included for external validation. Four machine learning models, including logistic regression (LR), decision tree (DT), random forest (RF), and gradient boosting machine (GBM), were utilized. Model performance was assessed by comparing the area under the curve (AUC) for each model. An LR-based nomogram model was constructed to assess patients' clinical prognosis. Results: Lasso regression identified eight associated factors: age, sex, maximum tumor diameter, nerve or vascular invasion, TNM stage, gastrectomy type, lymphocyte count, and carcinoembryonic antigen (CEA) level. The performance of these models was evaluated using the AUC. In the training group, the AUC values were 0.795, 0.759, 0.873, and 0.853 for LR, DT, RF...