Association of air temperature exposure during pregnancy with risk of preeclampsia in Guangzhou, China

作者：Shanshui Zeng, Haojing Liu, Bingyu Li, Xuanjie Guo, Shulei Chen, Xuyu Li, Jiarui Liang, H.J. Liang, Tingting Shen, Yan Long, Hongwei Zhou, Dongxin Zhang · 发表于：Environment International · 年份：2024 · DOI：10.1016/j.envint.2024.108646 · 被引用次数：16 · 研究领域：Climate Change and Health Impacts、Birth, Development, and Health、Pregnancy and preeclampsia studies

Environmental exposures during pregnancy have been associated with adverse obstetric outcomes. However, limited and inconsistent evidence exists regarding the association between air temperature exposure and the risk of preeclampsia (PE). This study aimed to evaluate the correlation between ambient temperature exposure during pregnancy and PE risk, as well as identify the specific time window of temperature exposure that increases PE risk. A population-based cohort study was conducted from January 2012 to April 2022 in Guangzhou, China. Pregnant women were recruited in early pregnancy and followed until delivery. A total of 3,314 PE patients and 114,201 normal pregnancies were included. Ambient temperature exposures at different gestational weeks were recorded for each participant. Logistic regression models were used to evaluate the correlation between ambient temperature exposure and PE risk. Stratified analyses were conducted based on maternal age and pre-pregnancy BMI. Distributed lag models were employed to identify the time window of temperature exposure related to PE. Exposure to extreme high temperature (aOR = 1.24, 95 % CI 1.12-1.38) and moderate high temperature (aOR = 1.22, 95 % CI 1.10-1.35) during early pregnancy was associated with an increased risk of PE. Furthermore, women with higher pre-pregnancy BMI had a higher risk of developing PE when exposed to high temperature during early pregnancy compared to normal-weight women. The time window of temperature expos...