Antimicrobial-resistant Neisseria gonorrhoeae in Europe in 2020 compared with in 2013 and 2018: a retrospective genomic surveillance study

作者：Daniel Golparian, Michelle Cole, Leonor Sánchez-Busó, Michaela Day, Susanne Jacobsson, Thinushaa Uthayakumaran, Raquel Abad, Béatrice Berçot, Dominique A. Caugant, Dagmar Heuer, Klaus Jansen, Sonja Pleininger, Paola Stefanelli, David M. Aanensen, Benjamin Bluemel, Magnus Unemo, Sonja Pleininger, Silke Stadlbauer, Alexander Indra, Irith De Baetselier, Wim Vanden Berghe, Amaryl Lecompte, Blaženka Hunjak, Tatjana Nemeth Blažić, Panayiota Maikanti-Charalambous, Despo Pieridou, Hana Zákoucká, Helena Žemličková, Steen Hoffmann, Susan Cowan, Lasse Jessen Schwartz, Rita Peetso, Jevgenia Epštein, Jelena Viktorova, Béatrice Berçot, Cécile Bébéar, Florence Lot, Jukka Torvikoski, Suvi Korhonen, Susanne Buder, Klaus Jansen, Vivì Miriagou, Eirini Siatravani, Ioanna Magaziotou, Eleni Paparizou, Eszter Balla, Mária Dudás, Lena Rós Ásmundsdóttir, Guðrún Svanborg Hauksdóttir, Þórólfur Guðnason, Maríanna Þórðardóttir, Aoife Colgan, Brendan Crowley, Sinéad Saab, Maeve Keane, Paola Stefanelli, Anna Carannante, Patrizia Parodi, Gatis Pakarna, Raina Nikiforova, Antra Bormane, Elīna Dimiņa, Christopher Barbara, Francesca Mifsud, Robert Cassar, Julie Haider, Alje P. van Dam, Birgit van Benthem, Maartje Visser, Ineke Linde, Hilde Kløvstad, Dominique Caugant, Thea Bergheim, Beata Młynarczyk-Bonikowska, Jacinta Azevedo, Maria José Borrego, Marina Lurdes Ramos Nascimento, Peter Pavlik, Irena Klavs, Andreja Murnik, Tanja Kustec, Polona Maver Vodičar, Julio Vázquez Moreno, Asunción Díaz, Raquel Abad Torreblanca, Inga Veličko, Magnus Unemo · 发表于：The Lancet Microbe · 年份：2024 · DOI：10.1016/s2666-5247(23)00370-1 · 被引用次数：55 · 研究领域：Reproductive tract infections research、Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections

BACKGROUND: Regular quality-assured whole-genome sequencing linked to antimicrobial resistance (AMR) and patient metadata is imperative to elucidate the shifting gonorrhoea epidemiology, both nationally and internationally. We aimed to examine the gonococcal population in the European Economic Area (EEA) in 2020, elucidate emerging and disappearing gonococcal lineages associated with AMR and patient metadata, compare with 2013 and 2018 whole-genome sequencing data, and explain changes in gonococcal AMR and gonorrhoea epidemiology. METHODS: In this retrospective genomic surveillance study, we analysed consecutive gonococcal isolates that were collected in EEA countries through the European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) in 2020, and made comparisons with Euro-GASP data from 2013 and 2018. All isolates had linked AMR data (based on minimum inhibitory concentration determination) and patient metadata. We performed whole-genome sequencing and molecular typing and AMR determinants were derived from quality-checked whole-genome sequencing data. Links between genomic lineages, AMR, and patient metadata were examined. FINDINGS: 1932 gonococcal isolates collected in 2020 in 21 EEA countries were included. The majority (81·2%, 147 of 181 isolates) of azithromycin resistance (present in 9·4%, 181 of 1932) was explained by the continued expansion of the Neisseria gonorrhoeae sequence typing for antimicrobial resistance (NG-STAR) clonal complexes (CCs) 63, 168...