Chiral P,N,N‐Ligands for Asymmetric Hydrogenation

作者：Dinghua Liang, Chuan‐Jin Hou, Qi Li, Hao Qin, Ling Li, Xiang‐Ping Hu · 发表于：Advanced Synthesis & Catalysis · 年份：2024 · DOI：10.1002/adsc.202400092 · 被引用次数：16 · 研究领域：Asymmetric Hydrogenation and Catalysis、Surface Chemistry and Catalysis、Carbon dioxide utilization in catalysis

Abstract The chiral P,N,N‐ligands represented a new type of tridentate ligand developed in recent years and displayed wide utilities in asymmetric catalysis. In the past decades, numerous chiral P,N,N‐ligands with ferrocene, phenethylamine and spiro backbones were synthesized by addition of an aminopyridine, imidazole or diamines coordinating group. These chiral tridentate P,N,N‐ligands showed excellent performance in the ruthenium, iridium, manganese, or cobalt‐catalyzed asymmetric hydrogenations. A wide range of substrates, including simple ketones, α‐halogenated ketones, α‐hydroxy ketones, α‐ or β‐amino keto‐ ones, α‐, γ‐, or δ‐keto acids, α‐ or β‐keto amides, β‐ or δ‐keto esters, α‐ or β‐enones, olefins, imines, quinolines and indoles, could be hydrogenated to afford the corresponding chiral products with high yields and enantioselectivities. In this review, progress on the asymmetric hydrogenation of C=O, C=N, C=C bonds with chiral tridentate P,N,N‐ligands was summarized.