Ferrocene-Based Antioxidant Self-Healing Hydrogel via the Biginelli Reaction for Wound Healing

作者：Rui Yuan, Zhao Fang, Fang Liu, Xianzhe He, Sa Du, Nan Zhang, Qiang Zeng, Yen Wei, Yuwei Wu, Lei Tao · 发表于：ACS Macro Letters · 年份：2024 · DOI：10.1021/acsmacrolett.4c00063 · 被引用次数：14 · 研究领域：Antimicrobial agents and applications、biodegradable polymer synthesis and properties、Ferrocene Chemistry and Applications

The development of antioxidant wound dressings to remove excessive free radicals around wounds is essential for wound healing. In this study, we developed an efficient strategy to prepare antioxidant self-healing hydrogels as wound dressings by combining multicomponent reactions (MCRs) and postpolymerization modification. A polymer containing ferrocene and phenylboronic acid groups was developed via the Biginelli reaction, followed by efficient modification. This polymer is antioxidant due to its ferrocene moieties and can rapidly cross-link poly(vinyl alcohol) to realize an antioxidant self-healing hydrogel through dynamic borate ester linkages. This hydrogel has low cytotoxicity and is biocompatible. In in vivo experiments, this hydrogel is superior to existing clinical dressings in promoting wound healing. This study demonstrates the value of the Biginelli reaction in exploring biomaterials, potentially offering insights into the design of other multifunctional polymers and related materials using different MCRs.