Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

作者：Felicia Djurijanto, Shyh‐Hsiang Lin, Nguyen-Phong Vo, Nguyen Quoc Khanh Le, Anh Nguyen‐Hoang, Szu‐Chuan Shen, Chung‐Hsin Wu, Jianyu Chen, Ngan Nguyen · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102578 · 被引用次数：23 · 研究领域：Gastrointestinal motility and disorders、Seed and Plant Biochemistry、Complementary and Alternative Medicine Studies

Background Constipation is prevalent worldwide, significantly increasing healthcare costs and diminishing the quality of life in children affected. Current studies have yielded mixed results regarding the factors associated with constipation, and mainly focusing on patients outside of Asia. Moreover, most of these studies lack focus on the paediatric population. This study aimed to identify the prevalence and associated factors of constipation among children in Asia. Methods In this systematic review and meta-analysis, we systematically searched PubMed, Scopus, and Cochrane for cohort and cross-sectional studies published from database inception up to October 12, 2022, and continued with manual searching until September 2, 2023. Eligible studies were those that included children in Asia aged 0–18 years old suffering from idiopathic constipation, with prevalence value provided in the English abstract. The analysis included clinical and general population. Children with organic constipation, who had undergone gastrointestinal surgery, or with congenital defects were excluded, as these factors affect the incidence of constipation. Data included in the analysis were extracted from published reports only. The extracted data were pooled using random-effects model to analyse the prevalence of constipation in children in Asia. This study is registered with PROSPERO, CRD42022367122. Findings Out of 4410 systematically searched studies and 36 manually searched ones, a total of 50 studi...