Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles

作者：Yanchuan Li, Yu Zhang, Jinxin Wang, Dingding Xia, Miaomiao Zhuo, Lu Zhu, Dong Li, Shao‐Fei Ni, Yanping Zhu, Weidong Zhang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c00671 · 被引用次数：24 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Radical Photochemical Reactions

Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task. Herein, we report a three-component strategy to afford diverse isoxazolines and isoxazoles via [3 + 2] cycloadditions of in situ-formed nitronates and olefins/alkynes under visible-light irradiation.