Association between metabolic syndrome severity score and cardiovascular disease: results from a longitudinal cohort study on Chinese adults

作者：Jingjing Lin, Pinyuan Dai, Jie Zhang, Yun-qi Guan, Weiwei Gong, Min Yu, Le Fang, Ruying Hu, Qingfang He, Na Li, Lixin Wang, Mingbin Liang, Jie-ming Zhong · 发表于：Frontiers in Endocrinology · 年份：2024 · DOI：10.3389/fendo.2024.1341546 · 被引用次数：11 · 研究领域：Diabetes, Cardiovascular Risks, and Lipoproteins、Health Promotion and Cardiovascular Prevention、Lipoproteins and Cardiovascular Health

Objective This study aimed to quantify the severity of metabolic syndrome(MetS) and investigate its association with cardiovascular disease(CVD) risk on Chinese adults. Methods 13,500 participants from the Zhejiang Adult Chronic Disease Study were followed up between 2010 and 2021. A continuous MetS severity score derived from the five components of MetS was used to quantify MetS severity, and the association between MetS severity and the risk of incident CVD was assessed using Cox proportional hazard and restricted cubic spline regression. Results Both the presence and severity of MetS were strongly associated with CVD risk. MetS was related to an increased risk of CVD (hazard ratio(HR):1.700, 95% confidence interval(CI): 1.380–2.094). Compared with the hazard ratio for CVD in the lowest quartile of the MetS severity score, that in the second, third, and highest quartiles were 1.812 (1.329–2.470), 1.746 (1.265–2.410), and 2.817 (2.015–3.938), respectively. A linear and positive dose-response relationship was observed between the MetS severity and CVD risk ( P for non-linearity = 0.437). Similar results were found in various sensitivity analyses. Conclusion The MetS severity score was significantly associated with CVD risk. Assessing MetS severity and further ensuring intervention measures according to the different severities of MetS may be more useful in preventing CVD.