Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis

作者：Yuxin Zhang, Yanjiao Zhang, Min Li, Jiaxing Tian, Xiaolin Tong · 发表于：Journal of Neurogastroenterology and Motility · 年份：2024 · DOI：10.5056/jnm23100 · 被引用次数：12 · 研究领域：Gastrointestinal motility and disorders、Regulation of Appetite and Obesity、Diet and metabolism studies

Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on the relationship between gastrointestinal dynamics and DGP has received much attention because of the increasing prevalence of DGP. Gastrointestinal motility disorders are closely related to a variety of factors including the absence and destruction of interstitial cells of Cajal, abnormalities in the neuro-endocrine system and hormone levels. Therefore, this study will review recent literature on the mechanisms of DGP and gastrointestinal motility disorders as well as the development of prokinetic treatment of gastrointestinal motility disorders in order to give future research directions and identify treatment strategies for DGP.