Advancing Guideline-Directed Medical Therapy in Heart Failure: Overcoming Challenges and Maximizing Benefits

作者：Zixi Zhang, Cancan Wang, Tao Tu, Qiuzhen Lin, Jiabao Zhou, Yunying Huang, Keke Wu, Zeying Zhang, Wanyun Zuo, Na Liu, Yichao Xiao, Qiming Liu · 发表于：American Journal of Cardiovascular Drugs · 年份：2024 · DOI：10.1007/s40256-024-00646-4 · 被引用次数：36 · 研究领域：Heart Failure Treatment and Management、Potassium and Related Disorders、Cardiac pacing and defibrillation studies

The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjustments in GDMT titration may be necessary based on patient characteristics, and every clinician is responsible for promptly initiating GDMT and titrating it appropriately within the patient's tolerance range. This review examines the current challenges in GDMT implementation and scrutinizes titration considerations within distinct subsets of HF patients, with the overarching goal of enhancing the adoption and effectiveness of GDMT. The authors also underscore the significance of establishing a novel management strategy that integrates cardiologists, nurse practitioners, pharmacists, and patients as a unified team that can contribute to the improved promotion and implementation of GDMT.