STI IN TIMES OF PREP: HIGH PREVALENCE OF CHLAMYDIA, GONORRHOEA, AND MYCOPLASMA AT DIF-FERENT ANATOMIC SITES IN MEN WHO HAVE SEX WITH MEN IN GERMANY

作者：Klaus Jansen, Gyde Steffen, Anja Potthoff, Ann-Kathrin Schuppe, Daniel Beer, Heiko Jessen, Stefan Scholten, Ragaller Spornraft, Viviane Bremer, Carsten Tiemann · 发表于：Figshare · 年份：2019 · DOI：10.5281/zenodo.3407406 · 研究领域：Reproductive tract infections research、Syphilis Diagnosis and Treatment、HIV, Drug Use, Sexual Risk

Background : Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. HIV-positive (HIV+) MSM often show higher STI-prevalence than HIV-negative MSM (HIV-). Approval of HIV pre-exposure prophylaxis (PrEP) might have influenced sexual behaviour and STI-prevalence of HIV- MSM. We estimated STI-prevalence and risk factors amongst HIV- and HIV+ MSM in Germany to plan effective interventions. Methods : We conducted a nationwide, cross-sectional study between 2/2018-7/2018. Thirteen MSM-friendly STI-practices screened MSM for Chlamydia trachomatis (CT) , Mycoplasma genitalium (MG), Neisseria gonorrhea (NG) , and Trichomonas vaginalis (TV) using self-collected rectal and pharyngeal swabs, and urine samples. APTIMA TM STI-assays (Hologic TM Inc., San Diego, USA) were used for diagnostics, and samples were not pooled. We collected information on socio-demographics, HIV-status, clinical symptoms, sexual behaviour within the last 6 months, and PrEP-use. We combined HIV status and PrEP use for defining risk groups, and used multivariate logistic regression to identify risk factors for STI. Results : 2,303 MSM were included: 50.5% HIV+, median age 39 [18-79] years. Median number of male sex partners within the last six months was 5. Unprotected anal intercourse (active and/or passive, UAI) was reported by 73.2%, 43.5% use of party drugs. 78.9% had ...