Exposure to Polybrominated Diphenyl Ethers and Risk of All-Cause and Cause-Specific Mortality

作者：Buyun Liu, Hans‐Joachim Lehmler, Ziyi Ye, Xing Yuan, Yuxiang Yan, Yuntian Ruan, Yi Wang, Yang Yu, Shuhan Chen, Wei Bao · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.3127 · 被引用次数：14 · 研究领域：Toxic Organic Pollutants Impact、Effects and risks of endocrine disrupting chemicals、Carcinogens and Genotoxicity Assessment

Importance: Polybrominated diphenyl ethers (PBDEs) are an important group of persistent organic pollutants with endocrine-disrupting properties. However, prospective cohort studies regarding the association of PBDE exposure with long-term health outcomes, particularly mortality, are lacking. Objective: To examine the association of environmental exposure to PBDEs with risk of all-cause and cause-specific mortality. Design, Setting, and Participants: This nationally representative cohort study used data from the National Health and Nutrition Examination Survey 2003 to 2004 and linked mortality information through December 31, 2019. Adults aged 20 years or older with available data on PBDE measurements and mortality were included. Statistical analysis was performed from February 2022 to April 2023. Exposures: PBDE analytes in serum samples were measured using solid phase extraction and isotope dilution gas chromatography high-resolution mass spectrometry. Main Outcomes and Measures: All-cause mortality, cancer mortality, and cardiovascular mortality. Results: This study included 1100 participants (mean [SE] age, 42.9 [0.6] years; proportion [SE] female, 51.8% [1.6%]; proportion [SE] Hispanic, 12.9% [2.7%]; proportion [SE] non-Hispanic Black, 10.5% [1.6%]; proportion [SE] non-Hispanic White, 70.8% [3.7%]; proportion [SE] other race and ethnicity, 5.8% [1.1%]). During 16 162 person-years of follow-up (median [IQR] follow-up, 15.8 [15.2-16.3] years; maximum follow-up, 17 years), 1...