Terpenoids from the Soft Coral Stereonephthya bellissima

作者：Xiaoli Yu, Xiao Han, Yue Mi, Yongpeng Cui, Anran Fu, Kun Liu, Xuli Tang, Guoqiang Li · 发表于：Journal of Natural Products · 年份：2024 · DOI：10.1021/acs.jnatprod.4c00112 · 被引用次数：9 · 研究领域：Marine Sponges and Natural Products、Microbial Natural Products and Biosynthesis、Coral and Marine Ecosystems Studies

A detailed chemical study of the extract from the soft coral Stereonephthya bellissima resulted in the isolation and identification of seven new sesquiterpenoids, bellissinanes A–G ( 1 – 7 ), along with four new diterpenes ( 8 – 11 ). Bellissinane A ( 1 ) is the third reported nardosinane-type sesquiterpene bearing a 6/5/6 tricyclic system. Bellissinanes C and D ( 3, 4 ) contain a phenylethylamine fragment, which is relatively unusual in marine organisms. Bellissinanes E–G ( 5 – 7 ) belong to the rare class of nornardosinane sesquiterpenoids. Structurally uncommon octahydro-1 H -indenyl-type and prenyleudesmane-type skeletons were characterized for herpetopanone B ( 8 ) and bellissimain A ( 9 ), respectively. Bellissinane E ( 5 ) exhibited in vivo angiogenesis-promoting activity.