Effects of saponins Rb1 and Re in American ginseng combined intervention on immune system of aging model

作者：Mao Shi, Jie Ma, Shan Jin, Tienan Wang, Yuhan Sui, Lina Chen · 发表于：Frontiers in Molecular Biosciences · 年份：2024 · DOI：10.3389/fmolb.2024.1392868 · 被引用次数：11 · 研究领域：Ginseng Biological Effects and Applications、Cancer-related molecular mechanisms research、Pharmacological Effects of Natural Compounds

Aging is a major risk factor for the development of many pathological processes, such as reduced immunity, cancer, cardiovascular diseases or neurodegenerative diseases, while age-related chronic diseases are the most common causes of death. This paper studies the effects of American ginseng saponin Rb 1 and Re alone and combined intervention on the immune system of aging mouse models, by using 30 mg/kg Rb 1 , 15 mg/kg Re, and Rb 1 + Re (30 mg/kg Rb 1 and 15 mg/kg Re (co-intervention) was used to intervene in the aging model, and immune indicators such as thymus index, spleen index, interleukin and interferon were detected to evaluate the impact of Rb 1 and Re on immune function. The results show that Rb 1 and Re intervention alone can increase the spleen index by 7%–12% and the thymus index by 12%–19% in the aging model. After Rb 1 or Re alone intervened, the apoptotic cells in the thymus were slightly reduced, and the proportion of apoptotic cells was reduced. The combination of Rb 1 + Re can promote the thymus index and spleen index to increase by 23.40% and 25.5% respectively, which is more advantageous than Rb 1 or Re alone. In addition, Rb 1 and Re intervention can reduce the level of interferon INF to a level comparable to that of young mice. Rb 1 + Re can not only reduce the INF content, but also reduce the TNF content. The above results show that American ginseng saponin Rb 1 and Re can delay the decline of the immune system in the aging model, and the combined inter...