Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes

作者：Zheng Wang, Brandilyn A. Peters, Bing Yu, Megan L. Grove, Tao Wang, Xiaonan Xue, Bharat Thyagarajan, Martha L. Daviglus, Eric Boerwinkle, Gang Hu, Yasmin Mossavar‐Rahmani, Carmen R. Isasi, Rob Knight, Robert D. Burk, Robert C. Kaplan, Qibin Qi · 发表于：Circulation Research · 年份：2024 · DOI：10.1161/circresaha.123.323634 · 被引用次数：72 · 研究领域：Gut microbiota and health、Metabolomics and Mass Spectrometry Studies、Nutritional Studies and Diet

BACKGROUND: Consistent evidence suggests diabetes-protective effects of dietary fiber intake. However, the underlying mechanisms, particularly the role of gut microbiota and host circulating metabolites, are not fully understood. We aimed to investigate gut microbiota and circulating metabolites associated with dietary fiber intake and their relationships with type 2 diabetes (T2D). METHODS: This study included up to 11 394 participants from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos). Diet was assessed with two 24-hour dietary recalls at baseline. We examined associations of dietary fiber intake with gut microbiome measured by shotgun metagenomics (350 species/85 genera and 1958 enzymes; n=2992 at visit 2), serum metabolome measured by untargeted metabolomics (624 metabolites; n=6198 at baseline), and associations between fiber-related gut bacteria and metabolites (n=804 at visit 2). We examined prospective associations of serum microbial-associated metabolites (n=3579 at baseline) with incident T2D over 6 years. RESULTS: We identified multiple bacterial genera, species, and related enzymes associated with fiber intake. Several bacteria (eg, Butyrivibrio , Faecalibacterium ) and enzymes involved in fiber degradation (eg, xylanase EC3.2.1.156) were positively associated with fiber intake, inversely associated with prevalent T2D, and favorably associated with T2D-related metabolic traits. We identified 159 metabolites associated with fiber intake, 47 of whi...