Economic Impact of Progression from Mild Cognitive Impairment to Alzheimer Disease in the United States

作者：Feride Frech, Li Gui, Timothy Juday, Yingying Ding, Soeren Mattke, Ara S. Khachaturian, Aaron S. Rosenberg, Colette Ndiba-Markey, A Rava, Richard Batrla, Susan De Santi, Heather Hampel · 发表于：The Journal of Prevention of Alzheimer s Disease · 年份：2024 · DOI：10.14283/jpad.2024.68 · 被引用次数：25 · 研究领域：Dementia and Cognitive Impairment Research、Alzheimer's disease research and treatments、Chronic Disease Management Strategies

BACKGROUND: Limited evidence exists on the economic burden of individuals who progress from mild cognitive impairment (MCI) to Alzheimer disease and related dementia disorders (ADRD). OBJECTIVES: To assess the all-cause health care resource utilization and costs for individuals who develop ADRD following an MCI diagnosis compared to those with stable MCI. DESIGN: This was a retrospective cohort study from January 01, 2014, to December 31, 2019. SETTING: The Merative MarketScan Commercial and Medicare Databases were used. PARTICIPANTS: Individuals were included if they: (1) were aged 50 years or older; (2) had ≥1 claim with an MCI diagnosis based on the International Classification of Diseases, Ninth Revision (ICD-9) code of 331.83 or the Tenth Revision (ICD-10) code of G31.84; and had continuous enrollment. Individuals were excluded if they had a diagnosis of Parkinson's disease or ADRD or prescription of ADRD medication. MEASUREMENTS: Outcomes included all-cause utilization and costs per patient per year in the first 12 months following MCI diagnosis, in total and by care setting: inpatient admissions, emergency department (ED) visits, outpatient visits, and pharmacy claims. RESULTS: Out of the total of 5185 included individuals, 1962 (37.8%) progressed to ADRD (MCI-to-ADRD subgroup) and 3223 (62.2%) did not (Stable MCI subgroup). Adjusted all-cause utilization was higher for all care settings in the MCI-to-ADRD subgroup compared with the Stable MCI subgroup. Adjusted all-ca...