Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome

作者：Ping Zhou, Penghui Feng, Baoying Liao, Lin Na Fu, Hongying Shan, Canhui Cao, Renxin Luo, Tianliu Peng, Fen-Ting Liu, Rong Li · 发表于：Journal of Ovarian Research · 年份：2024 · DOI：10.1186/s13048-024-01354-y · 被引用次数：23 · 研究领域：Ginseng Biological Effects and Applications、Gut microbiota and health、Ovarian function and disorders

Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut. Here, we summarize the role of gut microbiota dysbiosis in the development of PCOS and demonstrate the ability of different polyphenols - including anthocyanin, catechins, and resveratrol - to regulate gut microbes and alleviate chronic inflammation, thus providing new insights that may assist in the development of novel therapeutic strategies to treat women with PCOS.