The Enterics for Global Health (EFGH) Shigella Surveillance Study in The Gambia

作者：Bakary Conteh, Henry Badji, Abdoulie F Jallow, Mehrab Karim, Alhagie Manneh, B Kéita, Golam Sarwar, Bubacarr E Ceesay, Sheikh Jarju, Abdoulie Jabang, Ebrima Baldeh, Usman N. Ikumapayi, Ousman Secka, Martín Antonio, Anna Roca, Umberto D’Alessandro, Karen L. Kotloff, M Jahangir Hossain · 发表于：Open Forum Infectious Diseases · 年份：2024 · DOI：10.1093/ofid/ofae049 · 被引用次数：6 · 研究领域：Viral gastroenteritis research and epidemiology、Escherichia coli research studies、Child Nutrition and Water Access

Abstract Background The Gambia, located in West Africa, is one of 7 country sites conducting the Enterics for Global Health (EFGH) Shigella Surveillance Study to establish incidence and consequence of Shigella-associated medically attended diarrhea among children 6–35 months old. Methods Here we describe the study site and research experience, sociodemographic characteristics of the study catchment area, facilities of recruitment for diarrhea case surveillance, and known care-seeking behavior for diarrheal illness. We also describe The Gambia's healthcare system and financing, current vaccine schedule and Shigella vaccine adaptation, local diarrhea management guidelines and challenges, and antibiotic resistance patterns in the region. Conclusions The EFGH study in The Gambia will contribute to the multisite network of Shigella surveillance study and prepare the site for future vaccine trials. In addition, the data produced will inform policy makers about prevention strategies and upcoming Shigella vaccine studies among children in this setting.