An outbreak of hepatitis E virus genotype 4d caused by consuming undercooked pig liver in a nursing home in Zhejiang Province, China

作者：Ziping Miao, Kexin Cao, Xiaoyue Wu, Chenye Zhang, Jian Gao, Yin Chen, Zhou Sun, Xiaobin Ren, Yijuan Chen, Mengya Yang, Can Chen, Daixi Jiang, Yuxia Du, Xin Lv, Shigui Yang · 发表于：International Journal of Food Microbiology · 年份：2024 · DOI：10.1016/j.ijfoodmicro.2024.110682 · 被引用次数：9 · 研究领域：Hepatitis Viruses Studies and Epidemiology、Viral gastroenteritis research and epidemiology、Liver Disease and Transplantation

Hepatitis E infection is typically caused by contaminated water or food. In July and August 2022, an outbreak of hepatitis E was reported in a nursing home in Zhejiang Province, China. Local authorities and workers took immediate actions to confirm the outbreak, investigated the sources of infection and routes of transmission, took measures to terminate the outbreak, and summarized the lessons learned. An epidemiological investigation was conducted on all individuals in the nursing home, including demographic information, clinical symptoms, history of dietary, water intake and contact. Stool and blood samples were collected from these populations for laboratory examinations. The hygiene environment of the nursing home was also investigated. A case-control study was conducted to identify the risk factors for this outbreak. Of the 722 subjects in the nursing home, 77 were diagnosed with hepatitis E, for an attack rate of 10.66 %. Among them, 18 (23.38 %, 18/77) individuals had symptoms such as jaundice, fever, and loss of appetite and were defined as the population with hepatitis E. The average age of people infected with hepatitis E virus (HEV) was 59.96 years and the attack rate of hepatitis E among women (12.02 %, 59/491) was greater than that among men (7.79 %, 18/231). The rate was the highest among caregivers (22.22 %, 32/144) and lowest among logistics personnel (6.25 %, 2/32); however, these differences were not statistically significant (P > 0.05). Laboratory sequencin...