Population-wide active case finding as a strategy to end TB

作者：Thu Anh Nguyen, Alvin Kuo Jing Teo, Yanlin Zhao, M. Quelapio, Jeremy Hill, Fukushi Morishita, Ben J. Marais, Guy B. Marks · 发表于：The Lancet Regional Health - Western Pacific · 年份：2024 · DOI：10.1016/j.lanwpc.2024.101047 · 被引用次数：19 · 研究领域：Tuberculosis Research and Epidemiology、Pneumocystis jirovecii pneumonia detection and treatment、Infectious Diseases and Tuberculosis

Tuberculosis (TB) is the leading infectious cause of morbidity and mortality globally. Despite available tools for preventing, finding, and treating TB, many people with TB remain undiagnosed. In high-incidence settings, TB transmission is ubiquitous within the community, affecting both high-risk groups and the general population. In fact, most people who develop TB come from the general population. To disrupt the chain of transmission that sustains the TB epidemic, we need to find and treat everyone with infectious TB as early as possible, including those with minimal symptoms or subclinical TB who are unlikely to present for care. Important elements of an effective active case-finding strategy include effective social mobilisation and community engagement, using sensitive screening tools that can be used at scale, and embracing population-wide screening in high-incidence ('hot spot') areas. We require a better description of feasible delivery models, 'real-life' impact and cost effectiveness to enable wider implementation.