Impacts of futile reperfusion and reperfusion injury in acute ischemic stroke

作者：Ahmed Elmadhoun, Hongrui Wang, Yuchuan Ding · 发表于：Brain Circulation · 年份：2024 · DOI：10.4103/bc.bc_9_24 · 被引用次数：42 · 研究领域：Acute Ischemic Stroke Management、Stroke Rehabilitation and Recovery、Cardiac Ischemia and Reperfusion

Acute ischemic stroke (AIS) remains to be a challenging cerebrovascular disease. The mainstay of AIS management is endovascular reperfusion therapy, including thrombectomy and thrombolysis. However, ineffective (futile) reperfusion (FR) or reperfusion injury (RI) can be seen in a significant number of patients undergoing reperfusion strategy. In this article, we discuss two clinically relevant concepts known as "time window" and "tissue window" that can impact the clinical outcome of reperfusion therapy. We also explore patient risk factors, leading to FR and RI as well as an emerging concept of "no-reflow phenomenon" seen in ineffective reperfusion. These fundamental concepts provide insight into the clinical management of AIS patients and provide references for future research.