Papillary renal neoplasm with reverse polarity: an observational study of histology, immunophenotypes, and molecular variation

作者：Huan Han, Shu‐Yi Yin, Ruixiang Song, Jing Zhao, Yongwei Yu, Miaoxia He, Han Wang · 发表于：Translational Andrology and Urology · 年份：2024 · DOI：10.21037/tau-23-518 · 被引用次数：11 · 研究领域：Renal cell carcinoma treatment、Renal and related cancers、Medical Imaging and Pathology Studies

Background: Papillary renal neoplasm with reverse polarity (PRNRP) is a novel entity with unique clinicopathological characteristics, and only a small number of patients with PRNRP have been described. Methods: We retrospectively analyzed the data for nine patients with PRNRP and evaluated differences in the clinical, histomorphological, immunohistochemical, and molecular features; prognosis; and differential diagnosis of PRNRP from other renal tumors with papillary structure. Results: mutation in seven patients. All patients had a good prognosis after surgery and were relapse free. Positive staining for GATA3 and negative staining for vimentin were the most significant markers for differentiating PRNRP from other renal tumors with analogous structure. Conclusions: , and KRAS mutation are essential for pathological diagnosis. Owing to its satisfactory prognosis, the surveillance and follow-up of patients with PRNRP should be additionally formulated.