Ferroptosis in organ fibrosis: From mechanisms to therapeutic medicines

作者：Weijing Lai, Bo Wang, Rongshuang Huang, Chuyue Zhang, Ping Fu, Liang Ma · 发表于：Journal of Translational Internal Medicine · 年份：2024 · DOI：10.2478/jtim-2023-0137 · 被引用次数：41 · 研究领域：Ferroptosis and cancer prognosis、Circular RNAs in diseases、Cancer, Lipids, and Metabolism

Fibrosis occurs in many organs, and its sustained progress can lead to organ destruction and malfunction. Although numerous studies on organ fibrosis have been carried out, its underlying mechanism is largely unknown, and no ideal treatment is currently available. Ferroptosis is an iron-dependent process of programmed cell death that is characterized by lipid peroxidation. In the past decade, a growing body of evidence demonstrated the association between ferroptosis and fibrotic diseases, while targeting ferroptosis may serve as a potential therapeutic strategy. This review highlights recent advances in the crosstalk between ferroptosis and organ fibrosis, and discusses ferroptosis-targeted therapeutic approaches against fibrosis that are currently being explored.