Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

作者：Ji Wan, Zhongyi Nie, Jie Xu, Zixuan Zhang, Shenglian Yao, Zehua Xiang, Xiang Lin, Yuxing Lu, Chen Xu, Pengcheng Zhao, Yiran Wang, Jingyan Zhang, Yaozheng Wang, Shaotong Zhang, Jinzhuo Wang, Weitao Man, Min Zhang, Mengdi Han · 发表于：Science Advances · 年份：2024 · DOI：10.1126/sciadv.adm9314 · 被引用次数：61 · 研究领域：Advanced Sensor and Energy Harvesting Materials、Neuroscience and Neural Engineering、Wireless Body Area Networks

Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors mainly requires transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increases the risks of infection, reduces biocompatibility, or limits portability. Here, we develop a set of millimeter-scale, chip-less, and battery-less magnetic implants paired with a fully integrated wearable device for measuring biophysical and biochemical signals. The wearable device can induce a large amplitude damped vibration of the magnetic implants and capture their subsequent motions wirelessly. These motions reflect the biophysical conditions surrounding the implants and the concentration of a specific biochemical depending on the surface modification. Experiments in rat models demonstrate the capabilities of measuring cerebrospinal fluid (CSF) viscosity, intracranial pressure, and CSF glucose levels. This miniaturized system opens the possibility for continuous, wireless monitoring of a wide range of biophysical and biochemical conditions within the living organism.