Boosting Luminescence Efficiency of Near-Infrared-II Aggregation-Induced Emission Luminogens via a Mash-Up Strategy of π-Extension and Deuteration for Dual-Model Image-Guided Surgery

作者：Fulong Ma, Qian Jia, Ziwei Deng, Bingzhe Wang, Siwei Zhang, Jinhui Jiang, Guichuan Xing, Zhongliang Wang, Zijie Qiu, Zheng Zhao, Ben Zhong Tang · 发表于：ACS Nano · 年份：2024 · DOI：10.1021/acsnano.3c11078 · 被引用次数：46 · 研究领域：Luminescence and Fluorescent Materials、Nanoplatforms for cancer theranostics、Perovskite Materials and Applications

The simultaneous pursuit of accelerative radiative and restricted nonradiative decay is of tremendous significance to construct high-luminescence-efficiency fluorophores in the second near-infrared wavelength window (NIR-II), which is seriously hindered by the energy gap laws. Herein, a mash-up strategy of π-extension and deuteration is proposed to efficaciously ameliorate the knotty problem. By extending the π-conjugation of the aromatic fragment and introducing an isotope effect to the aggregation-induced emission luminogen (AIEgen), an improved oscillator strength ( f ), coupled with suppressed deformation and high-frequency oscillation in the excited state, are successively implemented. In this case, a faster rate of radiative decay ( k r ) and restricted nonradiative decay ( k nr ) are simultaneously achieved. Moreover, the preeminent emissive property of AIEgen in the molecular state could be commendably inherited by the aggregates. The corresponding NIR-II emissive AIEgen-based nanoparticles display high brightness, large Stokes shift, and superior photostability simultaneously, which can be applied for image-guided cancer and sentinel lymph node (SLN) surgery. This work thus provides a rational roadmap to improve the luminescence efficiency of NIR-II fluorophores for biomedical applications.