Shaping the immune‐suppressive microenvironment on tumor‐associated myeloid cells through tumor‐derived exosomes

作者：Hongmei Wang, Shanshan Liu, Jianhao Zhan, Yuqing Liang, Xiaoping Zeng · 发表于：International Journal of Cancer · 年份：2024 · DOI：10.1002/ijc.34921 · 被引用次数：16 · 研究领域：Extracellular vesicles in disease、Immune cells in cancer、Immune Cell Function and Interaction

Tumor-associated myeloid cells (TAMCs) play a crucial role in orchestrating the dynamics of the tumor immune microenvironment. This heterogeneous population encompasses myeloid-derived suppressor cells, tumor-associated macrophages and dendritic cells, all of which contribute to the establishment of an immunosuppressive milieu that fosters tumor progression. Tumor-derived exosomes (TEXs), small extracellular vesicles secreted by tumor cells, have emerged as central mediators in intercellular communication within the tumor microenvironment. In this comprehensive review, we explore the intricate mechanisms through which TEXs modulate immune-suppressive effects on TAMCs and their profound implications in cancer progression. We delve into the multifaceted ways in which TEXs influence TAMC functions, subsequently affecting tumor immune evasion. Furthermore, we elucidate various therapeutic strategies aimed at targeting TEX-mediated immune suppression, with the ultimate goal of bolstering antitumor immunity.