Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii served as key components of fecal microbiota transplantation to alleviate colitis

作者：Binqiang Xu, Yang Fu, Nuoming Yin, Wenfei Qin, Zehua Huang, Wei Xiao, Huizhen Huang, Qixiang Mei, Junjie Fan, Yue Zeng, Chunlan Huang · 发表于：American Journal of Physiology-Gastrointestinal and Liver Physiology · 年份：2024 · DOI：10.1152/ajpgi.00303.2023 · 被引用次数：25 · 研究领域：Clostridium difficile and Clostridium perfringens research、Gut microbiota and health、Gastrointestinal motility and disorders

We demonstrate that donors with high abundance of Bacteroides and Faecalibacterium ameliorate dextran sulfate sodium (DSS)-induced colitis in mice by fecal microbiota transplantation (FMT). The combination therapy of Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii is superior to mono-bacterial therapy in ameliorating colitis in mice, of which mechanism may involve promoting lecithin and inducing IL-10 production of intestinal Tregs.