Nonalcoholic Fatty Liver Disease: Changes in Gut Microbiota and Blood Lipids

作者：Keen Yang, Jieying Zeng, Huaiyu Wu, Huiyu Liu, Zhimin Ding, Weiyu Liang, Linghu Wu, Ziwei Lin, Wenhui Huang, Jinfeng Xu, Fajin Dong · 发表于：Journal of Clinical and Translational Hepatology · 年份：2024 · DOI：10.14218/jcth.2023.00199 · 被引用次数：8 · 研究领域：Liver Disease Diagnosis and Treatment、Gut microbiota and health、Metabolomics and Mass Spectrometry Studies

Background and Aims: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is 25%. This study aimed to explore differences in the gut microbial community and blood lipids between normal livers and those affected by NAFLD using 16S ribosomal deoxyribonucleic acid sequencing. Methods: Gut microbiome profiles of 40 NAFLD and 20 non-NAFLD controls were analyzed. Information about four blood lipids and 13 other clinical features was collected. Patients were divided into three groups by ultrasound and FibroScan, those with a normal liver, mild FL (FL1), and moderate-to-severe FL (FL2). FL1 and FL2 patients were divided into two groups, those with either hyperlipidemia or non-hyperlipidemia based on their blood lipids. Potential keystone species within the groups were identified using univariate analysis and a specificity-occupancy plot. Significant difference in biochemical parameters ion NAFLD patients and healthy individuals were identified by detrended correspondence analysis and canonical correspondence analysis. Results: were the most representative fatty-related bacteria. Glutamate pyruvic transaminase, aspartate aminotransferase, and white blood cell count were selected as the most significant biochemical indexes. Calculation of areas under the curve identified two microbiomes combined with the three biochemical indexes that identified normal liver and FL2 very well but performed poorly in diagnosing FL1. Conclusions: , combined with glutamate pyruvic transaminas...