Non-invasive diagnosis of bacterial and non-bacterial inflammations using a dual-enzyme-responsive fluorescent indicator

作者：Yue He, Majun Yang, Jingyi Cui, Can Zhao, Bin Jiang, Jiayun Guan, Xiaobo Zhou, Miao He, Yaya Zhen, Yuxue Zhang, Rongrong Jing, Qi Wang, Yuling Qin, Li Wu · 发表于：Chemical Science · 年份：2024 · DOI：10.1039/d3sc06866h · 被引用次数：10 · 研究领域：Drug-Induced Adverse Reactions、Streptococcal Infections and Treatments、Infective Endocarditis Diagnosis and Management

zebrafish experiments demonstrated the efficacy of CyQ in accurately discerning variations in NTR and NAD(P)H levels resulting from bacterial infection or LPS stimulation, thereby facilitating non-invasive detection of both bacterial and non-bacterial inflammations. The outstanding discriminatory ability of CyQ between bacterial and non-bacterial inflammation positions it as a promising clinical diagnostic tool for acute inflammations.