Multimodal digital assessment of depression with actigraphy and app in Hong Kong Chinese

作者：Jie Chen, Ngan Yin Chan, Chun-Tung Li, Joey Wing Yan Chan, Yaping Liu, Shirley Xin Li, Steven Wai Ho Chau, Kwong‐Sak Leung, Pheng‐Ann Heng, Tatia M.C. Lee, Tim M. H. Li, Yun Kwok Wing · 发表于：Translational Psychiatry · 年份：2024 · DOI：10.1038/s41398-024-02873-4 · 被引用次数：26 · 研究领域：Mental Health Research Topics、Digital Mental Health Interventions、Treatment of Major Depression

There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week of multimodal measurement including actigraphy and app-based measures (D-MOMO) to record rest-activity, facial expression, voice, and mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], and Artificial Neural Networks [ANN]) with leave-one-out cross-validation were applied to detect lifetime diagnosis of MDD and non-remission status. Eighty MDD subjects and 76 age- and sex-matched controls completed the actigraphy, while 61 MDD subjects and 47 controls completed the app-based assessment. MDD subjects had lower mobile time (P = 0.006), later sleep midpoint (P = 0.047) and Acrophase (P = 0.024) than controls. For app measurement, MDD subjects had more frequent brow lowering (P = 0.023), less lip corner pulling (P = 0.007), higher pause variability (P = 0.046), more frequent self-reference (P = 0.024) and negative emotion words (P = 0.002), lower articulation rate (P < 0.001) and happiness level (P < 0.001) than controls. With the fusion of all digital modalities, the predictive performance (F1-score) of ANN for a lifetime diagnosis of MDD was 0.81 and 0.70 for non-remission status when combined with the HADS-D item score, respectively. Multimodal digital measurement is a feasible dia...