Decoding the historical tale: COVID-19 impact on haematological malignancy patients—EPICOVIDEHA insights from 2020 to 2022

作者：Jon Salmanton‐García, Francesco Marchesi, Francesca Farina, Barbora Weinbergerová, Federico Itri, Julio Dávila, Sonia Martín‐Pérez, Andreas Birkedal Glenthøj, Ditte Stampe Hersby, María Gomes da Silva, Raquel Nunes Rodrigues, Alberto López‐García, Raúl Calvo Córdoba, Yavuz Memis Bilgin, Iker Falces‐Romero, Shaimaa El‐Ashwah, Ziad A. Emarah, Caroline Besson, Milena Kohn, Jaap A. van Doesum, Emanuele Ammatuna, Monia Marchetti, Jorge Labrador, Giovanni Paolo Maria Zambrotta, Luisa Verga, Ozren Jakšić, Márcio Nucci, Klára Piukovics, Alba Cabirta-Touzón, Moraima Jiménez, Elena Arellano, Ildefonso Espigado, Ola Blennow, Anna Nordlander, Stef Meers, Jens Vian Praet, Tommaso Francesco Aiello, Carolina García‐Vidal, Nicola Fracchiolla, Mariarita Sciumé, Güldane Cengiz Seval, Pavel P. Zak, Caterina Buquicchio, Carlo Tascini, Stefanie K. Gräfe, Martin Schönlein, Tatjana Adžić‐Vukičević, Valentina Bonuomo, Chiara M. Cattaneo, Summiya Nizamuddin, Martin Čerňan, Gaëtan Plantefève, Romane Prin, Tomáš Szotkovski, Graham P. Collins, Michelina Dargenio, Verena Petzer, Dominik Georg Friedrich Wolf, Natasha Čolović, Lucia Prezioso, Toni Valković, Francesco Passamonti, Gustavo‐Adolfo Méndez, Uluhan Sili, Antonio Vena, Martina Bavastro, Alessandro Limongelli, Rafael F. Duarte, Marie‐Pierre Ledoux, Milche Cvetanoski, Zlate Stojanoski, Marina Machado, Josip Batinić, Gabriele Magliano, Monika Biernat, Nikola Pantić, Christian Bjørn Poulsen, Annarosa Cuccaro, Maria Ilaria Del Principe, Austin Gladston Kulasekararaj, Irati Ormazabal‐Vélez, Alessandro Busca, Fatih Demırkan, Marriyam Ijaz, Н Н Климко, И. О. Стома, Sofya N. Khostelidi, Noemí Llamas Fernández, Ali Senosi Omrani, Rui Bergantim, Nick de Jonge, Guillemette Fouquet, Milan Navrátil, Ghaith F. Abu-Zeinah, Michail Samarkos, Johan A. Maertens, Cristina De Ramón, Anna Guidetti, Ferenc Magyari, Tomás José González‐López, Tobias Lahmer, Olimpia Finizio, Natasha Bahadur Ali, László Imre Pinczés, Esperanza Lavilla‐Rubira, Alessandra Romano, Maria Merelli, Mario Delia, María Calbacho, Joseph Meletiadis, Darko A. Antic, José‐Ángel Hernández‐Rivas, Joyce Marques de Almeida, Murtadha K. Al-Khabori, Martin Hoenigl, Maria Chiara Tisi, Nina Khanna, Aleksandra M. Barac, Noha Eisa, Roberta Di Blasi, Raphaël Liévin, Carolina Miranda, Nathan C. Bahr, Sylvain Lamure, Mario Virgilio Papa, Ayel Yahya, Avinash Aujayeb, Jan Novák, Nurettin Erben, María Fernández-Galán, José-María Ribera-Santa Susana, Ikhwan Rinaldi, Rita Fazzi, Monica Piedimonte, Rémy Duléry, Yung Bruno de Mello Gonzaga, Andrés Soto, Giuseppe Sapienza, Alexandra Serris, Ľuboš Drgoňa, Ana M. Groh, Laura Rubio i Serrano, Eleni Gavriilaki, Athanasios Tragiannidis, Juergen Prattes, Nicola Coppola, Vladimir Otašević, Miloš Mladenović, Mirjana Mitrović, Bojana Mišković, Pavel Jindra, Sofia Zompi, Maria Vittoria Sacchi, Carolin Krekeler, Evgenii Shumilov, María Stefania Infante, Daniel García-Bordallo, Gökçe Melis Çolak, Antonella Cingolani, Jiřı́ Mayer, Marianna Criscuolo, Marietta Nygaard, Michaela Hanáková, Luana Fianchi, Zdeněk Ráčil, Antonio Giordano, Martina Quattrone, Matteo Bonanni, Philipp A. Koehler, Laman Rahimli, Oliver A. Cornely, Livio Pagano, Francisco Javier Martín-Vallejo, Przemysław Zdziarski, Hossein Zarrinfer, Jana Wittig, Sein Win, Vivien Wai-Man, Benjamín Víšek, Donald Cuong Vinh, Maria J. G. T. Vehreschild, Gina Varricchio, Panagiotis D. Tsirigotis, Ana Torres-Tienza, Alina Tănase, Agostino Tafuri, MARIA I. STAMOULI, Jiří Sramek, Carole Soussain, Ayten Shirinova, Jörg E. A. Schubert, Enrico Schalk, Mohammad Reza Salehi, Modar Saleh, Giorgio Rosati, Elisa Roldán, Florian Reizine, Mayara Rêgo, Isabel Regalado‐Artamendi, Марина Алексеевна Попова, Fernando Campos Gomes Pinto, Laure Philippe, Hans Martin Orth, Hans Beier Ommen, Aleš Obr, Lucía Núñez-Martín-Buitrago, Nicolas Noël, Julia Neuhann, Gianpaolo Nadali, Julia Alexandra Nacov, Ana M. Munhoz Alburquerque, Maria Enza Mitra, Małgorzata Mikulska, Sibylle C. Mellinghoff, Ben Mechtel, Juan-Alberto Martín-González, Sandra Malak, Jorge Loureiro-Amigo, Lisset Lorenzo De La Peña, Giulia Liberti, Marianne Landau, Ira Lacej, Martin Kolditz, Chi Shan Kho, Reham Abdelaziz Khedr, Meinolf Karthaus, Linda Katharina Karlsson, María-Josefa Jiménez-Lorenzo, Macarena Izuzquiza, Baerbel Hoell-Neugebauer, Raoul Herbrecht, Christopher H. Heath, Fabio Guolo, Jan Hendrik Grothe, Antonio Giordano, Sergey Gerasymchuk, Ramón García‐Sánz, Nicole García‐Poutón, Vaneuza Araújo Moreira Funke, Monica Fung, Charlotte Flasshove, Luana Fianchi, Jenna Essame, Matthias Egger, Bernard Drénou, Giulia Dragonetti, Maximilian Desole, Roberta Della Pepa, Bénédicte Deau, Elizabeth de Kort, Erik De Cabo, François Danion, Étienne Daguindau, Tania Cushion, Louise Marie Cremer, Marianna Criscuolo, Gregorio Cordini, Antonella Cingolani, Fabio Ciceri, Fazle Rabbi Chowdhury, Ekaterina Yu. Chelysheva, Adrien Chauchet, Louis Yi Ann Chai, M. Mansour Ceesay, Elena Busch, Mathias Brehon, Davimar Miranda Maciel Borducchi, Stephen W. Booth, Serge Bologna, Caroline Berg Venemyr, Rebeca Bailén, Anastasia Antoniadou, Amalia N. Anastasopoulou, Fevzi Altuntaş · 发表于：EClinicalMedicine · 年份：2024 · DOI：10.1016/j.eclinm.2024.102553 · 被引用次数：34 · 研究领域：COVID-19 and healthcare impacts、COVID-19 Clinical Research Studies、SARS-CoV-2 and COVID-19 Research

Background: The COVID-19 pandemic heightened risks for individuals with hematological malignancies due to compromised immune systems, leading to more severe outcomes and increased mortality. While interventions like vaccines, targeted antivirals, and monoclonal antibodies have been effective for the general population, their benefits for these patients may not be as pronounced. Methods: The EPICOVIDEHA registry (National Clinical Trials Identifier, NCT04733729) gathers COVID-19 data from hematological malignancy patients since the pandemic's start worldwide. It spans various global locations, allowing comprehensive analysis over the first three years (2020-2022). Findings: The EPICOVIDEHA registry collected data from January 2020 to December 2022, involving 8767 COVID-19 cases in hematological malignancy patients from 152 centers across 41 countries, with 42% being female. Over this period, there was a significant reduction in critical infections and an overall decrease in mortality from 29% to 4%. However, hospitalization, particularly in the ICU, remained associated with higher mortality rates. Factors contributing to increased mortality included age, multiple comorbidities, active malignancy at COVID-19 onset, pulmonary symptoms, and hospitalization. On the positive side, vaccination with one to two doses or three or more doses, as well as encountering COVID-19 in 2022, were associated with improved survival. Interpretation: Patients with hematological malignancies still f...