Causal role of immune cells in major depressive disorder and bipolar disorder: Mendelian randomization (MR) study

作者：Yi Zhang, San-Wang Wang, Jiahao Ding, Xin Wen, Tingting Li, Lu Yang, Jintao Peng, Yingying Dong, Weifeng Mi, Yujun Gao, Guizhi Sun · 发表于：Research Square · 年份：2024 · DOI：10.21203/rs.3.rs-4097102/v1 · 研究领域：Tryptophan and brain disorders、Bipolar Disorder and Treatment、Diabetes and associated disorders

Abstract Major depressive disorder (MDD) and bipolar disorder (BD) are prevalent psychiatric conditions linked to inflammatory processes. This study employs a two-sample Mendelian randomization (MR) approach to investigate the relationship between immune cells and the risk of MDD and BD. Rigorous sensitivity analyses are conducted to assess the reliability, heterogeneity, and horizontal pleiotropy of the findings. The study reveals a significant association between immune cell profiles and the susceptibility to MDD and BD. Specifically, 29 immunophenotypes exhibit a substantial connection with MDD risk, including CD27 on IgD + CD38 − unswitched memory B cell (inverse variance weighting (IVW): odds ratio(OR) [95%]: 1.017[1.007 to 1.027], p = 0.001), CD27 on IgD + CD24 + (IVW: OR [95%]: 1.021 [1.011 to 1.031], p = 4.821×10 − 5), CD4 on Central Memory CD4 + T cell(IVW: OR [95%]:0.979 [0.963 to 0.995], p = 0.011) and the other 25 immunophenotypes. Additionally, 35 immunophenotypes demonstrate a significant association with BD risk, such as CD33br HLA DR + AC AC (IVW: OR [95%]: 1.022[1.007 to 1.036], p = 0.007), CD28 + CD45RA- CD8br %T cell RC (IVW: OR [95%]: 1.024 [1.008 to 1.041], p = 0.004) CD62L on CD62L + myeloid DC MFI (IVW: OR [95%]:0.926 [0.871 to 0.985], p = 0.014)), and the other 32 immunophenotypes. This MR study provides robust evidence supporting a causal relationship between immune cells and the susceptibility to MDD and BD, offering valuable insights for fu...