Macaque Brainnetome Atlas: A multifaceted brain map with parcellation, connection, and histology

作者：Yuheng Lu, Yue Cui, Long Cao, Zhenwei Dong, Luqi Cheng, Wen Wu, Changshuo Wang, Xinyi Liu, Youtong Liu, Baogui Zhang, Deying Li, Bokai Zhao, Haiyan Wang, Kaixin Li, Liang Ma, Weiyang Shi, Wen Li, Yawei Ma, Zongchang Du, Jiaqi Zhang, Hui Xiong, Na Luo, Yanyan Liu, Xiaoxiao Hou, Jinglu Han, Hongji Sun, Tao Cai, Qiang Peng, Linqing Feng, Jiaojian Wang, George Paxinos, Zhengyi Yang, Lingzhong Fan, Tianzi Jiang · 发表于：中国科学通报：英文版 · 年份：2024 · DOI：10.1016/j.scib.2024.03.031 · 被引用次数：20 · 研究领域：Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies、Fetal and Pediatric Neurological Disorders

The rhesus macaque (Macaca mulatta) is a crucial experimental animal that shares many genetic, brain organizational, and behavioral characteristics with humans. A macaque brain atlas is fundamental to biomedical and evolutionary research. However, even though connectivity is vital for understanding brain functions, a connectivity-based whole-brain atlas of the macaque has not previously been made. In this study, we created a new whole-brain map, the Macaque Brainnetome Atlas (MacBNA), based on the anatomical connectivity profiles provided by high angular and spatial resolution ex vivo diffusion MRI data. The new atlas consists of 248 cortical and 56 subcortical regions as well as their structural and functional connections. The parcellation and the diffusion-based tractography were evaluated with invasive neuronal-tracing and Nissl-stained images. As a demonstrative application, the structural connectivity divergence between macaque and human brains was mapped using the Brainnetome atlases of those two species to uncover the genetic underpinnings of the evolutionary changes in brain structure. The resulting resource includes: (1) the thoroughly delineated Macaque Brainnetome Atlas (MacBNA), (2) regional connectivity profiles, (3) the postmortem high-resolution macaque diffusion and T2-weighted MRI dataset (Brainnetome-8), and (4) multi-contrast MRI, neuronal-tracing, and histological images collected from a single macaque. MacBNA can serve as a common reference frame for mapp...