Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis

作者：Xinyong Liu, Longwang Chen, Wei Peng, Hongsheng Deng, Hongying Ni, Hongjie Tong, Hangbo Hu, Shengchao Wang, Jin Qian, Andong Liang, Kun Chen · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1356869 · 被引用次数：31 · 研究领域：Immune Response and Inflammation、Sepsis Diagnosis and Treatment、T-cell and B-cell Immunology

Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It is associated with high morbidity, rapid disease progression, and high mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation and antibiotic use, but their effectiveness is limited. Th17/Treg balance, based on its inflammatory property, plays a crucial role in determining the direction of the inflammatory response and the regression of organ damage in sepsis patients. This review provides a summary of the changes in T-helper (Th) 17 cell and regulatory T (Treg) cell differentiation and function during sepsis, the heterogeneity of Th17/Treg balance in the inflammatory response, and the relationship between Th17/Treg balance and organ damage. Th17/Treg balance exerts significant control over the bloom and wanes in host inflammatory response throughout sepsis.